New Blood Test Paves Way for Targeted Treatment for Prostate Cancer
A new three-in-one blood test that analyzes cancer DNA in the bloodstream before and during treatment will allow providers to understand and track which patients are likely to benefit from treatment with olaparib, a PARP inhibitor. Additionally, researchers found which genetic mutations prostate cancers use to resist treatment with olaparib. The study was published in Cancer Discovery.
FDA Approves Dabrafenib and Trametinib Combination for Metastatic NSCLC with BRAF V600E Mutation
On June 22, 2017, the U.S. Food and Drug Administration granted (FDA) regular approvals to dabrafenib and trametinib (Taflinar® and Mekinist®, Novartis Pharmaceuticals Inc.) administered in combination for patients with metastatic non-small cell lung cancer (NSCLC) with BRAF V600E mutation as detected by an FDA-approved test.
Recent FDA Approvals Continue to Focus on Targeted and Immunotherapy
Oncology clinicians can expect to continue to see new targeted and immunotherapy drugs emerge as clinically approved agents in the fight against cancer. Five cancer-related U.S. Food and Drug Administration (FDA) approvals occurred in the first quarter of 2017; following are their indications for treatment and associated clinical implications. You’ll recognize that some of the agents were already FDA approved for other uses, but as clinical trials continue and new data emerge, clinical use is expanding to other disease sites and indications.
Understanding Precision Medicine Therapeutics
Precision medicine involves the identification of actionable mutations and agents that target those specific pathways. ONS member Debra Wujcik, PhD, RN, FAAN, the director of research at Carevive Systems, Inc., gave an overview of precision medicine therapies at the Oncology Nurse Advisor Navigation Summit.
Ibrutinib May Improve GVHD Symptoms
Results from a new clinical trial have shown that the targeted therapy drug ibrutinib, a BTK inhibitor, can effectively treat graft-versus-host disease (GVHD), a common complication from allogeneic stem cell transplants. The study findings were reported at the American Society of Hematology’s 2016 annual meeting.
Do You Know the Best Practices for Targeted Medication Safety?
The Institute for Safe Medication Practices (ISMP) has added five new best practices and revised two existing ones for safe medication administration in its recent release of the 2016-2017 Targeted Medication Safety Best Practices for Hospitals.
Cancer Cells May Use Neutrophil Traps to Metastasize
Previous research has linked neutrophils to cancer metastasis, but a new study published in Science Translational Medicine may have uncovered more information about why this happens.
The study’s researchers found that neutrophil extracellular traps (NETs), which the immune system normally uses to kill harmful pathogens, may help metastatic cancer cells form new tumors in other parts of the body.