New Multiple Myeloma Treatments Present New Challenges in Side Effect Management
New strategies are emerging to manage the complex side effects and adverse events from multiple myeloma (MM) therapies, Lorraine Mack, APN/MSN CNL, OCN®, AOCNS®, and Dodi Georges, MSN, CWON, OCN®, both from Northwestern Medicine, said during a session held September 14, 2021, at the ONS BridgeTM virtual conference. They shared best practices for nursing interventions for patients undergoing new treatment options.
Diagnose and Treat Hypercalcemia of Malignancy
Hypercalcemia of malignancy (HCM) is a common paraneoplastic syndrome associated with poor prognosis that affects approximately 20%–30% of patients with cancer. It’s most often seen in patients with breast, lung, renal, or ovarian cancers; squamous cell carcinoma of the head and neck; multiple myeloma; and certain lymphomas.
An APRN’s Clinical Guide to Medical Marijuana
More and more patients with cancer are asking their healthcare providers whether medical marijuana can help them manage symptoms and side effects. Advanced practice RNs (APRNs) must be prepared to educate patients and assess their eligibility for therapeutic cannabis.
Nursing Management of Adverse Events From Enfortumab Vedotin Therapy for Urothelial Cancer
Once patients stop responding to platinum-based chemotherapy for locally advanced or metastatic urothelial cancer, their treatment options had been somewhat limited: PD-1/PD-L1 inhibitors were effective in only 13%–29% of patients and taxanes in only 11%–13%. When the antibody drug conjugate enfortumab vedotin was approved in late 2019, it offered new hope for patients and providers, with clinical trials reporting a 44% objective response rate.
What the Evidence Says About Music Therapy for Cancer-Related Fatigue
Cancer-related fatigue is a serious, debilitating symptom that affects nearly 90% of patients following treatment, with the majority reporting the adverse event at moderate to severe levels. It can prolong hospital stays and limit patients’ ability to complete their treatments and resume daily activities, ultimately affecting quality of life and survival. Despite high prevalence rates, cancer-related fatigue was reported as “inadequately addressed” in findings from a large multisite study.
Nurse Scientists Guide the Evidence in Symptom Science, and Inaugural Colloquium Recognizes That Impact on a National Level
Oncology nurses hold a unique position in improving symptom management and health outcomes in people with cancer, and their contributions to the body of symptom science are critical. In support of that work, ONS embarked on a landmark partnership with the National Institute of Nursing Research and National Cancer Institute's Center for Cancer Research to present the inaugural Colloquium on Symptom Science Advances in Oncology Nursing on February 4–5, 2021.
The Case of the Virtual Venture
Staff in an oncology infusion unit located in an urban healthcare system watched as patient and caregiver stress increased during the COVID-19 coronavirus pandemic and the November 2020 U.S. presidential elections. During a team meeting, Holly, one of the nurses, brought up a study she read about that used virtual reality (VR) as a distraction for patients undergoing chemotherapy. The staff was interested in implementing a similar program at their institution but wasn’t sure how to start. What would you do?
Manage Cancer Treatment-Related Constipation With ONS Guidelines™
As many as 43%–58% of patients with cancer experience constipation related to their treatment, and the side effect is both distressing and potentially life threatening if severe enough. Constipation-related emergency department visits increased by 41.5% from 2006–2011, with older adults (aged 85 years or older) making up most of the visits. Estimates suggest that the cost of managing severe cancer-related constipation may range from $500 to more than $2,300 per person per month. Supporting patients who experience the side effect is critical for their well-being.
Patients With Gynecologic Cancers Have Significant Fatigue After Surgery
Forty-eight percent of women with gynecologic cancers report experiencing clinically significant fatigue after surgery that may continue six months (44%) and one (39%) year later, researchers reported in study findings published in Cancer.
ONS Center for Innovation Launches New Tool to Help Improve Patient Outcomes
Cancer treatment often causes symptoms that result in treatment delays and unplanned care, which adversely affects patient outcomes, healthcare costs, and patient satisfaction. To decrease those possibilities, the ONS Center for Innovation launched ONS On-Call™, an oncology-specific decision support tool to guide standardized, evidence-based symptom assessment and leverage ONS’s proprietary evidence-based resources for patient-reported symptoms. Designed by nurses, the cloud-hosted tool ensures best practices in the clinic and institution by providing nurses with guided, comprehensive, and evidence-based assessments that illuminate the causative factors of patients’ symptoms and experience.
Opioids Can Be Used Safely for Cancer-Related Pain
During the current opioid epidemic, a safe, balanced approach to pain management is imperative. In an ONS Bridge presentation, Jeannine M. Brant, PhD, APRN, AOCN®, FAAN, discussed the use of opioids in patients with cancer.
ONS Guidelines™ Offer Framework for Managing Treatment-Related Hot Flashes
Because of treatment effects on hormones, women with breast cancer and men with prostate cancer have an increased risk of frequent and severe hot flashes after treatment. As many as 80% of patients across both genders experience the symptom, which can have an impact on sleep, mood, energy, and sexual function.
Oncology Symptom Science Research Needs to Focus on New Therapies
Immunotherapy, emerging therapies, precision health, and biosignatures are the next frontier for oncology symptom science research, specifically patient-reported outcomes and immune-related adverse events, researchers reported during a presentation on September 8, 2020, at the inaugural ONS Bridge™ virtual conference.
The Case of the Pancreatic Phenomenon
Ronnie, a 68-year-old patient with stage IV pancreatic ductal adenocarcinoma, recently started palliative FOLFIRINOX chemotherapy, a regimen consisting of 5-fluorouracil, leucovorin, irinotecan, and oxaliplatin, every two weeks. During his toxicity evaluation, prior to starting his second cycle, he describes a few concerning symptoms that have been ongoing for several weeks, including unintentional weight loss of 15 kg over the last two months, significant bloating after meals, and frequent flatulence with oily stools that are difficult to flush.
What the Evidence Says for Use of Qigong in Patients With Cancer
Qigong is a mind-body practice that originated in China nearly five millennia ago. It integrates movement, meditation, and breath regulation to improve physical and emotional health. The actions are slow, gentle, flowing, repetitious, and weight-bearing and can be adapted or practiced while sitting, standing, or walking. Qigong styles and forms vary widely, depending on the school of thought and philosophy.
Managing Cancer-Related PTSD Starts With Acknowledgement
Post-traumatic stress disorder (PTSD) is often associated with survivors of military combat or natural disaster, such as refugees or veterans. However, patients with a current or past cancer diagnosis, and their loved ones, are at risk for developing cancer-related PTSD (CR-PTSD).
Myeloproliferative Neoplasm Symptoms, Diagnosis, Treatment, and Survivorship Recommendations
Myeloproliferative neoplasms are a group of blood cancers that start with a small mutation in the stem cells of the bone marrow. Although MPNs are quite rare, essential thrombocythemia, polycythemia vera, and myelofibrosis are the most common types. Each represents a mutation of a different source of stem cell.
Cardio-Oncology Program Monitors Heart Toxicities Throughout Survivorship
Cancer is second only to heart disease as the leading cause of death in the United States. But heart conditions overlap with cancer in more ways than mortality. Chemotherapy, immunotherapy, radiation, and the myriad medication combinations used in cancer can lead to various complications, including cardiotoxic side effects. Because of the prevalence of heart disease, many patients with cancer also present with pre-existing cardiac comorbidities.
Does Cryotherapy Prevent Extremity Toxicities From Taxane Chemotherapy?
As many as 50% of patients receiving taxane chemotherapy have reported experiencing peripheral neuropathy (PN) or nail changes during treatment. Both are potentially dose-limiting adverse events: nail changes can lead to infections; PN affects patients’ ability to perform activities of daily living and results in sensory impairments such as loss of balance, muscle weakness, and numbness that can increase patients’ risk for falls.
Experts Recommend Tailored Exercise for All Cancer Treatment Plans
Systemic use of exercise prescriptions not only lowers the risk of certain cancers but also helps to improve side effects and survival from cancer and should therefore be incorporated into cancer treatment plans, experts from the American College of Sports Medicine and 17 partner organizations said in articles published in Medicine and Science in Sports and Exercise and CA: A Cancer Journal for Clinicians.
Draft ONS Guideline Open for Public Comment
As part of the rigorous process of transitioning ONS Putting Evidence Into Practice recommendations into formal, actionable clinical practice guidelines, the draft guidelines must undergo a public comment period. The first five guidelines to reach that step will be open for public comment in December 2019 and early 2020.
How Can Oncology Nurses Collaborate With Dietitians to Manage Malnutrition?
Nutrition impact symptoms (NIS) involve any barrier to a patient’s nutritional status. Cancer and its treatments often lead to complex side effects that develop rapidly and change in character and intensity throughout treatment. Barriers to eating and drinking, digesting, and absorbing nutrients lead to negative clinical outcomes for patients with cancer, including malnutrition. Prompt assessment and interventions are key to helping patients avoid treatment holidays and dose reductions while also promoting the best possible quality of life during their cancer journey. In fact, a weight loss of just 5% is an indicator that a patient will likely not receive all of his or her prescribed cancer treatment.
Manage Cancer-Associated Anemia With Erythropoietin-Stimulating Agents
As a side effect of cancer or its treatment, anemia is associated with reduced quality of life, thanks to symptoms such as palpitations, fatigue, dyspnea, and dizziness. Etiology is often multifactorial with contributing factors such as suppression of hematopoiesis from malignancy or cancer treatments, bleeding, nutritional deficiencies, renal insufficiency, or hemolysis.
Pneumonitis With Immunotherapy Treatment
Pneumonitis is inflammation of the lung parenchyma; although rare, it can be fatal. Nishino et al. found that the overall incidence of pneumonitis with PD-1 inhibitor monotherapy was 2.7% for all-grade and 0.8% for grade 3 or higher pneumonitis. Naidoo et al. reported an approximate 5% incidence of all-grade pneumonitis, although the incidence of all-grade pneumonitis is higher with combination immunotherapy (up to 10%). The incidence is more common with higher grades in PD-1 inhibitors (versus PD-L1 inhibitors), but it occurs less often with anti-CTLA4 monoclonal antibodies.
To Prevent Hepatoxicity, Monitor Liver Function During Cancer Treatment
Because the liver is the primary site of metabolism for many drugs, baseline function testing and monitoring during cancer treatment are essential. However, the cause of an abnormal liver function test when a patient is receiving chemotherapy or immunotherapy can be difficult to determine.
Evidence Shows Tai Chi May Be Useful for Insomnia
Nearly 60% of people with cancer experience insomnia; it can persist for years if not appropriately managed. Furthermore, patients with cancer who have insomnia are at increased risk for infections, anxiety, and depression, which can negatively affect quality of life.
Diagnose and Manage Dermatologic Toxicity Secondary to Immunotherapy
Dermatologic toxicity is the most common side effect secondary to immunotherapy. The majority of dermatologic adverse events are mild to moderate rashes on the truck of the body and upper extremities, pruritis, and vitiligo. The most common is maculopapular rash with erythematous macules, papules, and/or plaques that can sometimes be scaly; pruritis is also frequent but often underreported and undertreated and may affect quality of life.
FDA Approves Ruxolitinib for Acute Graft-Versus-Host Disease
On May 24, 2019, the U.S. Food and Drug Administration (FDA) approved ruxolitinib (Jakafi®) for steroid-refractory acute graft-versus-host disease (GVHD) in adult and pediatric patients 12 years and older.
Acupuncture for Cancer-Related Fatigue
Fatigue is one of the most prevalent and challenging side effects that people with cancer experience. Commonly known as cancer-related fatigue (CRF), the National Comprehensive Cancer Network defines it as “a distressing, persistent, subjective sense of physical, emotional, and/or cognitive tiredness or exhaustion related to cancer or cancer treatment that is not proportional to recent activity and interferes with usual functioning.” CRF affects 50%–90% of patients and can diminish quality of life, lead to functional impairment, and is associated with significant morbidity. Although it improves in many patients the year following treatment, CRF may persist over a much longer period in some.
The Case of the Terrible Toxicities
After completing neoadjuvant chemotherapy for triple-negative invasive breast cancer, Madeline, age 32, had a bilateral mastectomy with reconstructive surgery. Final pathology showed residual disease in the breast and one lymph node, and her oncologist recommended adjuvant therapy with capecitabine (1,500 mg twice a day for 14 days, off for 7 days). Five weeks postoperatively, she started cycle 1. Eight days later, her husband called the cancer clinic reporting that over the past two days, his wife developed profound weakness, unremitting diarrhea despite using diphenoxylate and atropine as directed, and painful, red, swollen hands and feet. Her symptoms represented a drastic change from her usual routine and energy level.
Tachycardia Tied to Higher Mortality in Patients With Cancer
Rates of all-cause mortality in patients with cancer increase in the presence of unexplained sinus tachycardia, the results of a new study show. Researchers presented the findings at the Advancing Cardiovascular Care of the Oncology Patient conference held January 2019 in Washington, DC.
Early Intervention Can Help Preserve Function in Spinal Cord Compression
Spinal cord compression (SCC)—an oncologic emergency—is the initial presentation in roughly 20%–33% of patients with a malignancy, Carol S. Viele RN, MS, OCN®, of the University of California, San Francisco, School of Nursing, said during a session on Saturday, April 13, 2019, at the ONS 44th Annual Congress in Anaheim, CA. Nurses can play a key role in recognizing the condition and getting patients into early treatment that may help preserve their function, she said.
Nurses Must Help Patients Use Cannabis Safely
Regardless of their own feelings or biases about cannabis, nurses must recognize that their patients are using it and help them to access the drug safely, Eloise Theisen, MSN, RN, AGPCNP-BC, of the Radicle Health Clinician Network in Walnut Creek, CA, said during a session on Saturday, April 13, 2019, at the ONS 44th Annual Congress in Anaheim, CA. Many patients with cancer are using cannabis and are looking to their healthcare providers for information on how they can use it to reduce their symptoms, she said.
Here’s How ONS Is Transitioning Symptom Management Resources Into Guidelines
Using the best evidence to inform care leads to better patient outcomes and can prevent over- or underuse of healthcare resources. Clinical practice guidelines are an important tool for healthcare providers to ensure they are using informed care in their practice. On Friday, April 12, 2019, at the ONS 44th Annual Congress in Anaheim, CA, Pamela Ginex, EdD, RN, discussed ONS’s symptom management guidelines and a new initiative to develop and implement guidelines into clinical care.
Nurses Need to Recognize the Unique Needs of Older Adults With Cancer
The number of U.S. adults aged 65 and over is rapidly increasing: by 2030, they’re estimated to represent about 70% of cancer diagnoses. During a session on Friday, April 12, 2019, at the ONS 44th Annual Congress in Anaheim, CA, speakers discussed how the complexities of cancer care can affect the expanding population of older adults with cancer.
Which of the Following Late Symptoms of Increased Intracranial Pressure Is Not Included in the Cushing Triad?
Which of the Following Late Symptoms of Increased Intracranial Pressure Is Not Included of the Cushing Triad?
A. Hypertension with widening pulse pressure
D. Abnormal respirations
Smartphone App Helps Patients Manage Cancer Pain
A smartphone app that monitors patients’ self-reported cancer pain and uses artificial intelligence (AI) to differentiate urgent and non-urgent issues and provide real-time recommendations significantly reduced pain and pain-related hospital admissions, researchers reported in an abstract presented at the November 2018 Palliative and Supportive Care in Oncology Symposium in San Diego, CA.
Opioids Have Been a Healthcare Concern Since the 1980s, but Here’s How Nurses Can Help
Although the opioid crisis was formally labeled a public health emergency in late 2017, excess drug abuse beyond prescription directions has been a public health concern for much longer—since the 1980s, in fact. At the November 2018 Center for Advancing Palliative Care Annual Seminar in Orlando, FL, speakers Lynn Hallarman and Mary McPherson presented a session on how the opioid crisis came to be and what our role as nurses is in changing culture and ultimately addressing it.
What You Need to Know About Caring for Geriatric Patients With Cancer
Cancer is largely a disease of an aged population. Estimates suggest that about 60% of all cancers are diagnosed in individuals aged 65 or older, and that number is expected to increase to 70% by 2030. Yet many nurses have little formal geriatric-specific training to care for this population’s unique needs.
Bipartisan Drug Pricing Bill; Freshman Democrats; Medical Cannabis Concerns
As efforts continue to drive down the soaring costs of prescription medications, Senators Chuck Grassley (R-IA) and Ron Wyden (D-OR) proposed a bipartisan bill looking to close loopholes used by pharmaceutical companies to drive up profits. The bill would give the Department of Health and Human Services the ability to address companies that misclassify products to pay lower rebates.
How Can Oncology Nurses Support Surgical Patients With Esophageal Cancer?
In 2000, I was diagnosed with stage III esophageal cancer—adenocarcinoma—and was put on a treatment regimen of chemotherapy, radiation therapy, and ultimately surgery to my esophagus. After talking with my doctors and nurses, heartburn was determined to be the cause of cancer. I didn’t realize at the time that survival rates for my disease were extremely low.
Under the Knife: Supporting Patients’ Needs Throughout Surgical Oncology Care
People often use idioms—such as “going under the knife” as a euphemism for surgery—to avoid confronting distressing situations, which is even more pronounced when it comes to life events as serious as cancer. But for many patients with cancer, undergoing a surgical procedure is key to positive outcomes, and they count on the expert clinical care and support of their surgical oncology nurses to see them through it.
Mobile Health Technology Provides Symptom Management Information for Pediatric BMT Recipients
Improved monitoring of pediatric patients undergoing blood and marrow transplant (BMT) may result in better precision symptom management strategies. Mobile health and wearable technologies may aid in such efforts by providing data on complex symptom patterns, trajectories, and interactions. Researchers conducted a pilot study and found that integrating mobile health technology into care was feasible, although they had concerns about compliance. Nirmish Shah, MD, of Duke University School of Medicine in Raleigh, NC, discussed the findings at the ASH Annual Meeting on December 3, 2018.
Research Shows That Telephone Triage Is a Vital Part of Patient Experience
The field of telehealth encompasses many efforts in oncology practice and research. When focusing specifically on telephone triage, we examine patient-initiated requests, such as speaking directly with their nurses on the phone, reporting side effects, or seeking answers to questions about plan of care and treatment. This provides oncology nurses with an opportunity for assessment and intervention. Although many current research efforts focus on proactive phone calls nurses make to their patients, it is also important to understand the impact of incoming calls on patient care and workflow.
Nutritional Support Reduces Weight Loss for Patients With Head and Neck Cancer
As many as 50% of patients with head and neck cancer experience pretreatment weight loss. In addition, treatment frequently involves chemotherapy and radiation, which can also result in weight loss, as well as mucositis and dysphagia, which can affect patients’ ability to eat. This could lead to treatment delays that may impact treatment efficacy.
Tailored Psychotherapy Combats Depression in Advanced Cancer
Just three to six sessions of a tailored psychotherapy program called CALM, or Managing Cancer and Living Meaningfully, reduced symptoms of depression or prevented the onset of depression in patients with recently diagnosed advanced cancer, according to findings from a study published in the Journal of Clinical Oncology.
How Oncology Nurses Provide Quality Care Through Telephone Triage
As a direct line to the oncology team, the phone conversations between nurses and their patients can help address symptoms, foster valuable patient education, provide useful interventions, encourage side effect reporting, and identify potentially life-threatening situations. Ultimately, successful telephone triage requires a unique skill set for oncology nurses to communicate with their patients and recognize underlying issues.
An APP-Led Infusion Center Can Reduce Hospital Use for Patients With Cancer
Emergency department visits by patients with cancer can be unnecessary, costly, and potentially dangerous. Most symptom management concerns can be safely and quickly handled in the outpatient setting, but provider access can be a barrier.