Cancer survivors from historically marginalized racial and ethnic groups who experience racism are more likely to report physical, mental, sleep, and activity issues during survivorship, researchers reported in study results published in Cancer. 

More than twice as many of today’s cancer survivors say they’re experiencing functional limitations after their disease than those in 1999, according to study findings published in JAMA Oncology. The prevalence was also nearly twice as high as that reported in the general population, but it varied by diagnosis and was disproportionately higher among Black and Hispanic survivors.

Alleviating the effects of persistent poverty on cancer outcomes requires building research capacity, fostering cancer prevention research, and promoting the implementation of community-based programs. To enhance the United States’ capacity to do so, the Biden-Harris administration awarded $50 million in June 2023 to create five new Centers for Cancer Control Research in Persistent Poverty Areas that will advance the Cancer Moonshot’s priorities.

Biomedical breakthroughs for cancer have enhanced research and discovery at record rates, giving patients extraordinary survivorship opportunities. It is a remarkable, unprecedented time. At the vanguard of understanding is the role of biomarkers and identifying each patient’s unique cancer signature through biomarker testing. Through the testing process, patients and providers can better determine an appropriate, individualized treatment path.

Pausing endocrine therapy to give breast cancer survivors an opportunity to attempt pregnancy does not increase their short-term recurrence rates, researchers reported in study findings presented at the 2022 San Antonio Breast Cancer Symposium. Additionally, survivors’ conception rates are on par or higher than those among the general public.

From President Richard Nixon’s war on cancer in 1971 to President Joe Biden’s commitment to “ending cancer as we know it” in 2022, fighting the disease has been a bipartisan focus. Yet in that era, when cancer hit home, policymakers often hushed their own diagnoses. But times change, and many of today’s lawmakers are now boldly sharing their personal experiences with cancer as inspiration for action.

Increases in early-stage lung cancer diagnoses with low-dose computed tomography screening have led to sustained improvements in survival rates more than 20 years later, researchers said while presenting their study findings at the 2022 Radiological Society of North America annual meeting.

U.S. Senators Ben Cardin (D-MD) and Amy Klobuchar (D-MN) and U.S. Representatives Debbie Wasserman Schultz (D-FL), Brian Fitzpatrick (R-PA), and Mark DeSaulnier (D-CA) introduced the Comprehensive Cancer Survivorship Act in December 2022 to address gaps in survivorship care and formulate standards to improve quality of cancer care and navigation needs of survivors.

Regular use of aspirin after an advanced colorectal cancer diagnosis may extend survival by as much as 14 months for patients with a healthy body mass index score prediagnosis compared to those with obese BMIs, researchers reported in JAMA Network Open.

Monitoring early-stage testicular cancer survivors for disease recurrence after surgery using either magnetic resonance imaging or fewer computed tomography scans is just as effective as more frequent intervals, researchers reported in study findings published in the Journal of Clinical Oncology.

The cancer survivorship program team at the University of Pennsylvania Abramson Cancer Center is conducting numerous research projects such as cancer treatment’s late effects, survivors’ quality of life and health behaviors, telemedicine for survivorship visits, and even an artificial intelligence–powered, mobile phone–based program to support patient adherence to guidance from survivorship visits.

Not understanding terms like deductible, copay, premium, coinsurance, and out-of-pocket maximum prevents many Americans from selecting a health insurance plan that meets their financial needs. Fewer than 40% of patients enrolled in high-deductible healthcare plans engage in effective financial behaviors, such as comparing prices or discussing costs with clinicians. High costs are a barrier for many patients and survivors to access high-quality cancer and survivorship care.

With care shifting to outpatient delivery and the increased availability of evidence-based support services, cancer care and survivor support has greatly evolved during the past 25 years, according to ONS member Carlin Callaway, DNP, MS, RN, ACNP-BC, ACNS-BC, AOCNP®, assistant professor and lead medical oncology advanced practice provider at the University of Colorado Cancer Center and member of the ONS Metro Denver Chapter, in a June 2022 public-facing blog post for the American Society of Clinical Oncology’s Cancer.Net website.

Coordinating survivorship care plans is an integral part of cancer care. When the Froedtert and Medical College of Wisconsin Cancer Network experienced challenges in implementing survivorship care plans, it created a brand-new medical role—survivorship data coordinator—to “initiate case findings for eligible patients, track patients completing treatment, notify physicians and advanced practice providers to populate the survivorship care plan, and schedule survivorship care plan appointments.”

Survivors need support to resume a high-quality, healthy “new normal” life after they complete their treatment. The services of a cancer survivorship clinic or program may help them manage the physical and emotional implications involved with ongoing care.

A greater increase in cancer survivorship may be an outcome from Medicaid expansion under the Affordable Care Act (ACA), according to study results published in the Journal of Clinical Oncology in May 2022.

Access and reimbursement, patient and provider education, core competencies, and survivorship research funding remain critical barriers for primary central nervous system (CNS) cancer survivorship, a team of National Cancer Institute Comprehensive Oncology Network Evaluating Rare CNS Tumors experts reported in a workshop summary published in Neuro-Oncology Advances.

Patients with higher levels of digital health literacy have more positive survival outcomes during cancer, researchers reported in study findings published in JCO Clinical Cancer Informatics.

Babies born to adult survivors of childhood cancers are as healthy as those born to adults without a history of cancer, but survivors have a higher risk of severe complications during pregnancy, researchers reported in the Journal of the National Cancer Institute.

A novel stem cell transplantation strategy reduces both the incidence and severity of chronic graft-versus-host disease (GVHD) in patients with acute leukemia, researchers reported in the Journal of Clinical Oncology. The investigational treatment removes naïve T cells from donor cells before transplanting into patients.

Some people may be overjoyed at the prospect of completing their cancer treatment and returning to normal life, but for many others, fear and anxiety can overshadow feelings of elation. The survivorship phase of a cancer journey can be confusing and uncertain. Comments like, “I don’t know what is next” and “The responsibility for care is now up to me” can alert oncology nurses that patients need additional communication and strategies to transition into healthy survivorship.

Patients younger than 40 who elected to have breast-conserving surgery instead of mastectomy to remove breast cancer reported having better quality of life (QOL) more than five years after diagnosis, according to study findings reported in JAMA Surgery.

More than 150 Office of Cancer Survivorship grants totaling nearly $112 million funded research on cancer survivorship in 2020, including “resources for implementation of the STAR Act and additional resources provided through legislation such as the 21st Century Cures Act, which authorized funding for the Cancer Moonshot,” according to the office’s 25th anniversary report.

Adolescent and young adults (AYAs)—those diagnosed between the ages of 15 and 39—comprise about 5% of all annual cancer diagnoses. The population has unique challenges that must be considered as part of patient-centered survivorship care planning.

Among patients with metastatic, castration-resistant prostate cancer, treatment with the experimental ¹⁷⁷Lu-PSMA-617 radiopharmaceutical, along with other standard treatments, improved survival by four months over treatment with standard therapies alone, researchers reported in the New England Journal of Medicine. The therapy targets the PMSA protein and may one day be an option when other treatments have failed.

Using two agents that target two different receptors more than doubles length of survival for advanced melanoma than a single agent alone, researchers reported at the 2021 American Society of Clinical Oncology annual meeting.

In 2021, approximately 44,000 people will be diagnosed with thyroid cancer, most commonly younger patients and assigned females at birth.

Progression-free and overall survival rates for patients with metastatic testicular cancer have significantly grown since 1990, researchers reported in the Journal of Clinical Oncology.

In April 2021, U.S. Senators Chris Murphy (D-CT) and Joni Ernst (R-IA) introduced the Metastatic Breast Cancer Access to Care Act, legislation that would waive the five-month waiting period for social security disability insurance (SSDI) and the 24-month waiting period for eligible Medicare benefits.

As Americans reduce tobacco use and treatment and diagnosis advance, lung cancer survivorship rates are improving; however, it still remains the second most common type of cancer. The growing population needs appropriate survivorship care.

Historically, ovarian cancer is often diagnosed at advanced stages because of vague symptoms and presentation, but with new advancements in diagnosis and treatment options, patients with the disease are living longer than ever.

As the number of cancer survivors continues to grow in the United States, so too does the need for cancer survivorship programs. Oncology advanced practice RNs (APRNs) are essential team members as institutions develop and deliver comprehensive and holistic programs to meet survivors’ needs.

Chronic pain is a common but debilitating late effect for many patients with cancer. When undertreated, patients may experience negative functional, mental, and cancer-related outcomes. Although opioids are often effective for managing cancer pain, they may not be appropriate for some patients and others may struggle to access them because of the opioid crisis. The need for nonpharmacologic pain management options is critical. 

Despite accounting for only 3% of all cancer survivors, patients with head and neck cancers often require significant support and survivorship care. And oncology nurses can expect survivorship to grow with recent improvements in prognosis and treatment options, such as with reductions in human papillomavirus-related oropharyngeal cancers, which tend to affect young people and offer improved long-term survival rates.

As the third most common cancer among both men and women, colorectal cancer is a reality for the more than 1 million people in the United States who are living with or have a history of the disease. Advancements in early detection and treatment have improved outcomes, but many survivors experience late and long-term side effects that may vary in duration, intensity, and impact on their quality of life. Clinicians must tailor each survivorship care plan for a patient’s cancer type, stage, treatment received, psychosocial implications, and side effects or toxicities. Studies have shown that experiencing long-term side effects and symptoms can reduce survivors’ quality of life. 

As treatments have advanced and patients and providers have more options, cure and survivorship rates for lymphomas are improving: five-year survival rates for Hodgkin and non-Hodgkin lymphoma are 86% and 71%, respectively. Despite good results from treatment, research indicates that lymphoma survivors carry a significant amount of late and chronic effects. Even in a complete remission, late effects of treatment present a burden for patients' physical and psychosocial well-being.

More than 3.5 million people in the United States are living with a breast cancer diagnosis. Despite their large number, patients often report they do not receive appropriate follow-up care after completing treatment—and the situation is worsening, with pandemic-related delays in care affecting approximately half of breast cancer survivors.

Pancreatic cancer is the ninth most common cancer in the United States, accounting for 3% of all cancers but causing 7% of cancer-related deaths, which equates to about 57,500 diagnoses and 47,050 deaths each year. The average person’s risk for pancreatic cancer is about 1 in 64.

Lisa, a 32-year-old tax accountant, completed treatment for stage III triple-negative breast cancer 18 months ago. During a follow-up appointment, Lisa reported worsening headaches and difficulty concentrating at work. A magnetic resonance imaging scan and subsequent biopsy revealed a solitary brain lesion. She completed stereotactic brain radiation two months ago.

Lung cancer is the leading cause of cancer death in the United States, accounting for about one quarter of cancer deaths, and more than a quarter of million lung cancer diagnoses are projected in the United States for 2020. Lung cancer has various types, pathologies, and histologies, each with its own prognosis and treatment plan. Non-small cell lung cancer consists of about 80%–85% of lung cancer diagnoses.

Until recently, past ONS President Deborah Mayer, PhD, RN, AOCN^®, FAAN, served as interim director of the National Cancer Institute’s (NCI’s) Office of Cancer Survivorship, a part of the Division of Cancer Control and Population Sciences. As an oncology nurse, Mayer brought a special perspective to the office’s mission to better understand and meet the unique needs of the growing number of U.S. cancer survivors.

Glioblastoma or glioblastoma multiform (GBM) is a primary central nervous system tumor. Approximately 23,890 new brain tumors are diagnosed in the United States each year, with GBM accounting for 38%. GBM can present as a primary diagnosis or evolve from a lower grade brain tumor.

Users of two common antihistamines—desloratadine and loratadine—have lower mortality rates from cutaneous malignant melanoma than patients who use other antihistamines, researchers reported in Allergy.

Although opioid-related deaths are increasing in the general U.S. population, leading to the U.S. Department of Health and Human Services declaring it a public health emergency, new research shows that the increase is much smaller among patients with cancer, even though opioids are used as an option for cancer-related pain. The findings were published in JAMA Oncology.

Most cancer diagnoses in the United States occur later in life, in patients older than 60 years, although most of the common pediatric diagnoses occur in those younger than 10 years. Pediatric and adult patients receive similar cancer therapies. The goal is to kill rapidly dividing cancer cells. Unfortunately, most of a child’s cells also undergo rapid division, and treatment can damage healthy tissue. Therefore, treatment that cures pediatric cancer can also cause long-term survivorship issues.

Myeloproliferative neoplasms are a group of blood cancers that start with a small mutation in the stem cells of the bone marrow. Although MPNs are quite rare, essential thrombocythemia, polycythemia vera, and myelofibrosis are the most common types. Each represents a mutation of a different source of stem cell.

A child’s cancer diagnosis can tear apart a family’s sense of security. After successfully navigating the cancer experience and all that comes with it, no one wants to face that again, and patients and families may fear an increased risk for secondary cancers. Oncology nurses can support pediatric cancer survivors and their families with resources for monitoring and reassurance about the possibility of facing secondary cancer.

Primary care for patients who are cancer survivors is multifaceted. Although my goal as a primary care physician (PCP) remains the same as with all my patients—to continue helping them lead long, healthy lives—care for this population requires some additional steps.