Adding hyperthermic intraperitoneal chemotherapy (HIPEC) to interval cytoreductive surgery improves 10-year overall survival in patients with stage III epithelial ovarian cancer by nearly 40%, researchers reported in study findings published in Lancet Oncology. 

Black or Hispanic individuals, those who’ve received neoadjuvant chemotherapy, and older individuals are more likely to experience lymphedema after breast cancer treatment with axillary lymph node dissection and radiation therapy, researchers reported in JAMA Oncology. 

A patient’s race and the neighborhood in which they live can meaningfully lower time to progression and overall survival for triple-negative metastatic breast cancer, oncology nurse researchers reported in the Oncology Nursing Forum. 

Committing $5.4 million to their first year of study, the Biden-Harris administration announced its inaugural cohort of 11 Cancer Moonshot scholars in August 2023. The White House said that the emerging leaders in cancer research and innovation will use the funding “to help change what is possible.”

Race-specific cellular and genomic characteristics in breast and breast cancer tissues may explain racial differences in breast cancer aggressiveness, blood vessel growth, tumor cell migration and metastasis, and the cancer pathways GLI1 and Notch, researchers said in study findings published in npj Breast Cancer. The findings may help guide the development of even more personalized treatments and address some aspects of cancer’s disparate burden on certain populations. 

Cellular therapy has revolutionized cancer treatments and outcomes for many patients, and it may one day revolutionize the management of certain side effects as well. According to study findings published in eBioMedicine, induced pluripotent stem cell transplantation may help reverse chemotherapy’s endocrine and reproductive effects on female infertility. 

After remaining largely stable from 2011–2019, cancer incidence rates dropped sharply in 2020 while mortality remained level, the Centers for Disease Control and Prevention said in its 2023 U.S. Cancer Statistics report.

Pausing endocrine therapy to give breast cancer survivors an opportunity to attempt pregnancy does not increase their short-term recurrence rates, researchers reported in study findings presented at the 2022 San Antonio Breast Cancer Symposium. Additionally, survivors’ conception rates are on par or higher than those among the general public.

Because of insufficient evidence, the U.S. Preventive Services Task Force’s (USPSTF’s) 2023 skin cancer recommendations advise that “the balance of benefits and harms for visual skin examination by a clinician to screen for skin cancer in asymptomatic adolescents and adults cannot be determined.” For breast cancer, the USPSTF’s 2023 recommendation stated that all women should get screened every other year, starting at age 40.

Noting the complexity of the human brain and brain tumors, Lawrence Tabak, DDS, PhD, acting director of the National Institutes of Health (NIH), discussed in an April 2023 blog post the findings from a NIH-funded research that may suggest novel nanoparticles can help bypass the blood-brain barrier and deliver drugs to treat medulloblastoma, an aggressive brain cancer diagnosed in hundreds of children each year.

Personalizing cancer treatments through targeted drugs and customized doses can make strides in care for pediatric patients with cancer, cancer specialists said in the National Institutes of Health's News in Health.

Adding carboplatin to standard neoadjuvant chemotherapy for patients with triple-negative breast cancer improves complete response, event-free survival, and overall survival, researchers reported in study findings presented in abstract GS5-01 during the 2022 San Antonio Breast Cancer Symposium. 

Increases in early-stage lung cancer diagnoses with low-dose computed tomography screening have led to sustained improvements in survival rates more than 20 years later, researchers said while presenting their study findings at the 2022 Radiological Society of North America annual meeting.

Marking her first year at the National Cancer Institute (NCI), Katrina Goddard, PhD, director of the NCI’s Division of Cancer Control and Population Sciences, outlined a foundation of future research for DCCPS, priority research areas, and the impact of research on diverse populations in a December 2022 interview.

Most patients at high risk for developing pancreatic cancer whose disease was found while participating in a screening program were diagnosed with early-stage cancers, according to study findings published in the Journal of Clinical Oncology.

In a December 2022 statement, Monica M. Bertagnolli, MD, National Cancer Institute director,  announced that she was diagnosed with hormone receptor-positive, HER2-negative breast cancer and that her prognosis is favorable. She said she is enrolled in a clinical trial centered around her diagnosis to contribute to the cancer knowledge base and advance care.

Regular use of aspirin after an advanced colorectal cancer diagnosis may extend survival by as much as 14 months for patients with a healthy body mass index score prediagnosis compared to those with obese BMIs, researchers reported in JAMA Network Open.

Overall cancer death rates continued to decline from 2015–2019 among men, women, children, adolescents, and young adults in every major racial and ethnic group, according to the October 2022 Annual Report to the Nation on the Status of Cancer. The National Cancer Institute, Centers for Disease Control and Prevention, American Cancer Society, and North American Association of Central Cancer Registries jointly issue the report each year to monitor cancer trends across society.

Prescreening patients for immune-related adverse events during treatment with immune checkpoint inhibitors using text messaging may reduce the need for some in-person, preinfusion office visits, researchers reported in JAMA Network Open. The approach may help decrease the burden of cancer care for both patients and providers.

Equalizing the quality of patient-provider communication for Black versus White patients is one way to reduce the systemic racial disparities prevalent in cancer care, researchers reported in study findings published in the November 2022 issue of the Oncology Nursing Forum. They identified critical opportunities for oncology nurses to improve interpersonal communication with Black patients. Nurses are key drivers to affecting change and cancer outcomes for all patients, they reported.

Compared to their non-Hispanic White counterparts, most Hispanic patients with localized prostate cancer are nearly 20% more likely to have aggressive disease, but the risk varies based on their country of origin, researchers reported in study findings published in Prostate Cancer and Prostatic Diseases. Additionally, they found that the population faces disparities in access to care, with only approximately 60% receiving appropriate treatment.

Patients who engage in physical activity during or after cancer treatment are less fatigued and return to their usual daily activities faster than those who don’t exercise, researchers reported in JACC: CardioOncology. The benefit is highest among patients who are active during treatment but still pronounced for those who resume physical activity after completing treatment.

Regardless of residence, nearly 25% of patients with cancer overall miss at least 10% of the doses in their radiation treatment plans—but the implications on outcomes are far greater for patients living in rural areas than their urban counterparts, according to new research findings published in the International Journal of Radiation Oncology, Biology, Physics.

On December 16, 2022, the U.S. Food and Drug Administration approved nadofaragene firadenovec-vncg (Adstiladrin®) for adult patients with high-risk, Bacillus Calmette-Guérin unresponsive, carcinoma in situ, non–muscle-invasive bladder cancer with or without papillary tumors.

Overall survival among patients with non–muscle-invasive bladder cancer who are treated with adjuvant gemcitabine and docetaxel is comparable to overall survival for treatment with bacillus Calmette-Guérin (BCG), researchers reported in the Journal of Urology. The evidence could support a treatment alternative for high-risk patients during the BCG shortage.

Significant progress has been made with childhood cancer, especially with the efforts of Children's Oncology Group (COG), but some areas still need attention, Doug Hawkins, MD, COG chair, a National Cancer Institute (NCI)-funded network of researchers and hospitals, explained in a September 2022 interview with NCI.

Patients with advanced cancer who met with community health workers between their regular cancer care appointments were less likely to require acute care and more likely to participate in advance care planning and receive mental health, palliative, and hospice care, according to study findings published in JAMA Oncology.

Along with outlining monetary spending for the upcoming years, the National Cancer Institute’s 2024 annual plan and budget proposal highlights areas of opportunity to advance cancer research, Douglas R. Lowy, MD, who was NCI acting director at the time, said in a September 2022 NCI’s director message.

Patients with germline genetic variants that increase their risk of developing prostate cancer have a lower risk of developing lethal disease when following a healthy lifestyle, according to study findings that researchers reported in European Urology.

In her first report as National Cancer Institute director, Monica M. Bertagnolli, MD, laid out her eight core principles to guide the agency’s work in reformulating clinical trials and strengthening cancer research during the Clinical Trials Advisory Committee meeting in November 2022.

High levels of interleukin-6 (IL-6) and C-reactive protein before chemotherapy for breast cancer may predict a patient’s propensity to develop clinical decline and frailty after treatment, according to study findings that researchers reported in the Journal of Clinical Oncology.

My passion for biomarkers lies in research, specifically clinical trials. The incorporation of biomarkers in oncology clinical trials has been an important advancement in research, and we’ve seen the effect on improving patient outcomes. Identification of pathogenic variants is essential to prescribing personalized therapy for patients with cancer.

Biomarkers, also called molecular markers or signature molecules, can help clinicians characterize alterations in tumors through the detection of specific DNA, RNA, protein, or metabolomic profiles. These pieces of the cancer puzzle are part of precision oncology that the cancer care team can use to assess patients’ cancer risk and prognosis or monitor disease progression. Biomarkers are also a key factor in determining and tailoring treatment methods and their likelihood of success.

More than 95% of germline genetic variants identified through genetic testing in patients with lung cancer are potentially clinically actionable, researchers reported in study findings during the 2022 ASCO Plenary Series Program, leading them to recommend testing all patients with the disease.

Poorer outcomes among males receiving BRAF or MEK inhibitors for melanoma may be related to an increase in androgen receptors, researchers discovered in study findings published in Nature.

Our understanding of cancer has come a great ways over the past few decades, and some of the progress can be traced back to the 1950’s film Challenge: Science Against Cancer, explained David Cantor, PhD, researcher at the Instituto de Desarrollo Económico y Social, Buenos Aires Argentina, adjunct professor in the School of Public Health at the University of Maryland, College Park, in a July 2022 essay for the National Library of Medicine.

Caregivers spend an average of 30 hours per week caring for patients with metastatic prostate cancer, researchers reported in study findings published in the Journal of Clinical Oncology.

Cancer and its treatments can affect a patient’s body in many ways, including sexual function. However, the historical evidence base is focused on cisgender men and their sexual health post-cancer treatment, with sexual health of women and LGBTQIA+ patients largely ignored. I, and many others, are working to change these disparities in research and practice.

More than two-thirds of patients with hormone receptor–positive metastatic breast cancer respond to personalized immunotherapy with tumor-infiltrating lymphocytes and more than half of those treated experience measurable tumor shrinkage, according to study findings published in the Journal of Clinical Oncology.

Racial and ethnic groups are disproportionately affected by the increase in uterine cancer mortality in the United States, researchers explained in study findings published in JAMA Oncology, with Hispanic patients experiencing the highest burden.

A compound the body produces when fasting or following a ketogenic diet may slow or stop the growth of colorectal cancer (CRC) cells, according to study results published in Nature.

Although regular population-based skin cancer screening isn’t recommended by the U.S. Preventive Services Task Force, more Americans are getting full-body skin exams at dermatology visits or other provider services. Data from a new study published in JAMA Dermatology suggest that the screening uptick is associated with increased diagnoses of early-stage, in situ melanoma, leading the researchers to raise concerns about overdiagnosis.

In findings that could have global implications to change the face of female cancers, researchers reported that a single dose of the human papillomavirus (HPV) vaccine is highly effective in protecting young women against cervical infection with cancer-causing HPV types. The study results, which were published in NEJM Evidence, build on the body of evidence supporting single-dose HPV vaccines.

Financial considerations are notable barriers for patients with cancer receiving follow-up cancer care, according to study findings from the National Institutes of Health (NIH) All of Us Research Program.

Death rates fell about 2% per year from 1999–2019 for Black patients with cancer, researchers reported in study findings published in JAMA Oncology; however, the population’s cancer mortality remains higher than other racial and ethnic groups for most cancer sites.

Long-term exposure to wildfire smoke increases a person’s risk for developing lung and brain cancer by 5% and 10%, respectively, according to study findings published in Lancet Planetary Health.

In a clarion call for action seven years ago, President Barack Obama unveiled the Cancer Moonshot during his last State of the Union address. In that speech, Obama recalled, “Last year, Vice President Joe Biden said that with a new moonshot, America can cure cancer. Tonight, I’m announcing a new national effort to get it done. And I’m putting Joe in charge of Mission Control.”

Propensity to adhere to cervical cancer screening recommendations varies widely by sexual orientation, researchers reported in study findings published in Cancer. They found that those in sexual minority groups are nearly 50% less likely to have ever undergone a Pap test.

A greater increase in cancer survivorship may be an outcome from Medicaid expansion under the Affordable Care Act (ACA), according to study results published in the Journal of Clinical Oncology in May 2022.

Broad-based sex differences exist in the severity of side effects from cancer and its treatment, with female patients at an overall 34% higher risk for severe symptoms than male patients—and the risk jumps to nearly 50% for immunotherapies, researchers reported in the Journal of Clinical Oncology.