The correct answer is D. PTEN.
Cowden syndrome (multiple hamartoma syndrome) is characterized by multiple noncancerous, tumor-like growths called hamartomas. However, individuals with Cowden syndrome are at an increased risk for developing breast, thyroid, or endometrial cancers.
APC is associated with familial adenomatous polyposis; VHL is associated with Von Hippel-Lindau syndrome; and TP53 is associated with Li-Fraumeni syndrome.
Read more about Cowden syndrome.