Which Gene Is Associated With Cowden Syndrome (Multiple Hamartoma Syndrome)?

The Answer

The correct answer is D. PTEN. 

Cowden syndrome (multiple hamartoma syndrome) is characterized (https://ghr.nlm.nih.gov/condition/cowden-syndrome) by multiple noncancerous, tumor-like growths called hamartomas. However, individuals with Cowden syndrome are at an increased risk (https://ghr.nlm.nih.gov/condition/cowden-syndrome) for developing breast, thyroid, or endometrial cancers.

APC is associated with familial adenomatous polyposis; VHL is associated with Von Hippel-Lindau syndrome; and TP53 is associated with Li-Fraumeni syndrome.

Read more about Cowden syndrome (https://ghr.nlm.nih.gov/condition/cowden-syndrome).