May 30, 2023

Fumarate hydratase deficiency occurs in individuals who have homozygous pathogenic variants in the tumor suppressor FH gene. The condition results in poor feeding, failure to thrive, hypotonia, lethargy, and seizures. Development is severely delayed, and individuals are often nonverbal, unable to walk, and die in early childhood.

May 24, 2023

On May 22, 2023, the U.S. Food and Drug Administration (FDA) reported ICU Medical’s recall of replacement batteries for its Plum 360™, Plum A+™, and Plum A+3 infusion systems because of a manufacturing defect that can substantially diminish how long the batteries can run the system. FDA identified it as a class I recall, the most serious type of recall, where use may cause serious injuries or death.

May 24, 2023

Nearly all adolescent and young adult (AYA) patients with cancer who use the services of a population-specific clinic would recommend it to other AYAs with cancer, researchers reported during a session at the 48th Annual ONS Congress® in April 2023. They said that more than 90,000 AYAs aged 15–39 are diagnosed with cancer every year in the United States, a critical life stage in which cancer can deeply affect individuals’ social, developmental, educational, professional, and financial growth, making services like specialized clinics critical to an AYA patient population.

May 23, 2023

In an open-label, multicenter, multicohort study that included 90 patients with relapsed or refractory follicular lymphoma who had received at least two prior lines of systemic therapy, 60% of patients receiving treatment with mosunetuzumab-axgb achieved a complete response and 80% had an overall response. On December 22, 2022, the U.S. Food and Drug Administration granted mosunetuzumab-axgb accelerated approval based on those findings.

May 22, 2023

On May 19, 2023, the U.S. Food and Drug Administration granted accelerated approval to epcoritamab-bysp (Epkinly®) for relapsed or refractory diffuse large B-cell lymphoma (DLBCL) not otherwise specified, including DLBCL arising from indolent lymphoma, and high-grade B-cell lymphoma after two or more lines of systemic therapy.

May 18, 2023

Noting the complexity of the human brain and brain tumors, Lawrence Tabak, DDS, PhD, acting director of the National Institutes of Health (NIH), discussed in an April 2023 blog post the findings from a NIH-funded research that may suggest novel nanoparticles can help bypass the blood-brain barrier and deliver drugs to treat medulloblastoma, an aggressive brain cancer diagnosed in hundreds of children each year.