Only 65% of all U.S. teens have received the first dose of the human papillomavirus (HPV) vaccine—and only 48.6% of those teens are up to date with the series of HPV vaccinations. Studies have shown the HPV vaccination is effective at reducing the rates of cervix, vaginal, anal, and penile cancers. HPV vaccination rates have become a national health prevention priority, and oncology nurses can help lead the discussion about ways to prevent more than 90% of all HPV-related cancers.