Which Genetic Test Performed on Tumor Cells Has Prognostic and Predictive Uses?

Answer

The answer is D: Oncotype DX®.

Oncotype DX® is a 21-gene assay performed on breast tumor cells' RNA. It has both prognostic and predictive uses. Read more about Oncotype DX® here (https://cjon.ons.org/cjon/21/1/apply-resources-practice-use-current-genetics-and-genomics-content-oncology) and here (https://cjon.ons.org/cjon/17/3/individualizing-care-women-early-stage-breast-cancer-role-molecular-assays). 

BRCA1 is a genetic test; however, it is performed on the blood, not tumor cells. 

CA 27.29 is a breast cancer tumor marker, a substance secreted by the tumor and plays a significant role in staging and diagnosis.  

CTCs are used to detect microscopic metastases and may be prognostic of recurrence.